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Raman upstream bioprocess control

Nicro provides turnkey solutions for fermenters

This case study examines how Nicro moved from time-consuming sample analysis to real-time monitoring of critical parameters in their fermentation processes. The result? Inline process monitoring of metabolites without the need of offline sampling helped the company improve process control, leading to optimized production and increased yield.

Bioreactors in Nicro case study ©Endress+Hauser

The results

  • Faster process cycle times with less risk due to in-line,
    real-time process monitoring of metabolites

  • Improved process control leading to optimized
    production and increased yield

  • A complete technology packaged solution for fermentation processes

Customer challenges

A typical indicator of fermentation progress is the lack of dissolved oxygen in the media which gives an estimation of the process duration. Optical density and metabolites may also be monitored for better insight into the process. Concentration of metabolites would usually be measured off-line with time-consuming chromatographic techniques. This off-line sampling approach can bring a potential risk of contamination and lead to the loss of a valuable batch.

Our solution

Nicro combined its competencies together with BICRO BIOCentre and Endress+Hauser to provide a complete packaged solution for fermentation processes. It includes:

  • Engineering and design of a complete fermentation system from Nicro

  • An Endress+Hauser Raman Rxn analyzer and Rxn-45 probe, powered by Kaiser Raman technology

  • Analytical services from BICRO BIOCentre supported by S-PACT modelling services

Read the whole case study

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